Psidium guajava

Used by 4 traditions1 compound

Common Names

tcm: 番石榴 (Fan Shi Liu)

african: Mupeera (Luganda), Mpera (Swahili)

english: Guava, Common Guava

spanish: Guayaba

ayurveda: अमृतफल (Amritaphala)

latin_pharmaceutical: Psidii Guajavae Folium

Geographic Range: Native to Mexico, Central America, and Caribbean; now pantropically distributed. One of the most widely cultivated tropical fruits.

Known Contraindications

• May interact with antidiarrheal medications (additive effect)
• Caution in severe dehydration (treat dehydration first)
• Constipation (strong astringent)
• Prolonged use without reassessment
• May reduce absorption of concurrent oral medications
• Concurrent constipating medications
• Intestinal obstruction
• Excessive use can cause constipation
• Not used for diarrhea with high fever without addressing fever separately
• May interact with anti-diabetic drugs (leaf extract has mild hypoglycemic effect)
• High-dose leaf extract in pregnancy (limited safety data)
• Excessive consumption may cause constipation
• Excessive leaf tea may cause constipation (reverse the problem)
• Chronic constipation
• Potential interaction with antidiabetic medications (lowers blood glucose)
• Constipation (guava is binding/astringent)
• Dry-type conditions

Compounds

Traditions

Treatments

Conditions

CAS: 117-39-5

SMILES: OC1=CC(=C2OC(=CC(=O)C2O)C2=CC(O)=C(O)C=C2)C=C(O)C1=O

CYP Interaction Profile

Enzyme	Interaction
CYP1A2	weak inhibitor
CYP2C9	moderate inhibitor
CYP2D6	weak inhibitor
CYP3A4	moderate inhibitor
transporter	P-glycoprotein inhibitor — increases bioavailability of P-gp substrates
clinical_note	Moderate CYP3A4 and CYP2C9 inhibition. May increase levels of cyclosporine, digoxin, fexofenadine (P-gp effect). Poor oral bioavailability (< 5%) limits systemic interactions at dietary levels.